On the eve of their 20th anniversary, RJ's parents invite him to dueling dinners, and RJ is forced to choose between his mom and his dad. Meanwhile, Miles joins the cheerleading squad to lose weight.
Following a murder that appears to be a hate crime, Teresa risks tipping Gibbons off to her big-picture plan by boldly taking on the Chicago Police Department's corrupt "meritorious" promotion system. Meanwhile, Jarek is forced to face his own reality when Vonda receives an anonymous package that reveals more about the Wysocki family
Kaylie finally returns to training at The Rock, but the public is under the impression that her time away from the gym was from an ACL injury, not rehab for anorexia. Soon after, Sasha announces that Kelly Parker is going to replace Emily on the World team, and that Kaylie will be replaced, as well, since she has not had enough time to train.
Senior visits Mikey's gallery and is affected by paintings depicting their strained relationship. While both shops work on respective builds, Junior learns he has won his appeal of Senior's lawsuit, and Senior decides to make Junior a settlement offer.
When Balagan’s oldest friend, the larger than life Russian cosmonaut Oleg Olesky, comes to the Huxley, he brings more than the party. About to pilot the first private space tourism rocket ship, Oleg is there with Chase Galactic as they announce their maiden launch. When the head engineer, Randall, falls from the roof of the hotel, Oleg is the prime suspect. With his only alibi being the fact he was with his boss’s wife, which she denies, Oleg pleads for Balagan’s help. Balagan eventually figures out the true motive for Randall’s murder – and the real murderer.
Rob gives his mom, Patty, the full Hollywood superstar treatment when he casts her in an absurd commercial for a new credit card company he has invested in. Rob's cousin, Big Cat, loses a bet and is forced to appear in the commercial dressed as a "man-cat / ginger-lion", inspiring Rob and the crew to don red wigs and explore their "inner-gingers" for a day. At the red carpet premier of her commercial, Rob surprises Patty with an incredible special guest.
Victoria panics as her 30th birthday approaches, and drags Mike and Molly into her "life crisis".
Grace and Adrian shop for a wedding dress, and Amy is cornered into planning a baby shower for Adrian. Grace and Grant have relationship problems.
When Tiffany decides to leave New York because of her divorce, it means Connie must find a new job and Larry finally has a chance with his dream girl; however, they soon each get more than they bargained for.
The Daily News staff are stunned by the death of a colleague and it quickly becomes clear to Paddy that she is out of her depth. Assisted by handsome journalist, Terry, Paddy closes in on her prime suspect but without concrete proof no one will believe her so she plants evidence on him and informs the police. Suddenly realising she may have implicated the wrong man she confides in the one person at the newspaper she truly trusts, the once brilliant Dr Pete, a journalist of some repute now dying of cancer caused by a lifetime’s hard drinking. But her realisation comes too late.
When pre-med freshman Beth Garrett is found strangled to death, a mysterious text leads the detectives to a potential suspect. After some investigating at her sorority, the detectives learn that there is more to this mild mannered bookworm than initially meets the eye. Meanwhile, DDA's Dekker and Rubirosa are forced to change their strategy when game-changing evidence is discovered at the last minute.
As the gang prepares for prom, Dixon and Annie learn some troubling news about their futures, and Ivy discovers that Raj's health has taken a turn for the worse. With Silver away in the hospital, Adrianna tries to rekindle her romance with Navid. Meanwhile, Naomi and Max's relationship is strained to the breaking point.
Stan and Francine fight over how to redecorate the house. It goes so far that they split the house down the middle and try to live without each other. Meanwhile, Principal Lewis discovers a talent of Barry.
In the season finale, Horatio must capture an escapee again when their transport plane crashes. And the team was shocked to discover that the fugitive has planned more than that.
Mitch questions the validity of the police investigation while Richmond has to deal with a negative ad. It's discovered that Rosie was at Bennett's apartment the night she died.
Goren and Eames return to the Major Case Squad after a year-long absence and must determine if a banker was murdered or committed suicide. They discover the bank's only client is the Catholic Church and dig into a scandal and cover-up linked to the murder.
Margaret Bradley had Multiple Sclerosis and was living with her daughter, Rhonda, a nurse. A part-time aide helped Margaret while Rhonda was at work. In 2002, Margaret suddenly fell ill and died the next evening of unusual and dangerously low blood sugar levels. Rhonda, who knew her mother didn't have diabetes, looks into her mother's untimely end and wonders if her mother's death was really murder. Her search for answers would eventually lead authorities to open a criminal investigation.
Toni's investigation of a post-Katrina casualty gets more confusing at every turn; a routine closing at the bar for LaDonna becomes a disaster; Janette is forced to make a quick trip back to New Orleans to tend to a housing crisis; Nelson ups the ante in his business deal with Robinette; Antoine practices with his new band; Sonny turns to another musician for help when his home is vandalized.
Amy and Bob make up for not throwing Gabe his much delayed 12th birthday party by giving him a 12 ½ birthday party, after Gabe promised to be good for a whole week. Unfortunately, Gabe's party falls on the same day as a huge blizzard. Meanwhile, Ivy and Teddy cannot get along with Ivy not liking Teddy's new boyfriend Derek, which causes a rift in their friendship. They go to each other's houses to settle their differences, the same day as the snow storm. Teddy is driven crazy by Ivy's parents Mary Lou and Harry (Ellia English and William Allen Young) while Ivy is having a great time celebrating Gabe's 12-½ birthday. Meanwhile, PJ helps Bob lose a few pounds.