Malone's team joins forces with Gil Grissom, a CSI from Las Vegas, and his team as they track a serial killer with ties to New York. The crossover starts on CSI: Crime Scene Investigation S08E06 Who and What (I).
After Six cuts off Chode, he and Gus decide to hit a strip club. At the club, Chode is given a medallion that is supposedly a key to a treasure, but we soon find out its true purpose. Meanwhile, the rest of the crew are stuck in a tractor-beam, and the ship is running out of air...but they can't get away because Chode locked the controls when they left for the club.
Therapy unearths a repressed memory from Foxxy's past. Xandir gives Toot a makeover.
While everyone is asleep, a Castaway searches for the Hidden Immunity Idol, collecting random items in the desperate hope that one of them might be it.
Michael is feeling left out after finding out Ryan took a handful of branch managers and even Toby on a wilderness retreat, but didn't invite him. In order to get back with nature, Michael asks Jim if he would consider a camping trip together. Hypothetically, Jim answered yes.
Bela gets in the way yet again as Sam and Dean are investigating multiple victims who drowned even though they were nowhere near water. Sam and Dean make the creepy discovery that the victims all saw a ghost ship right before dying. They tell Bela to stay away, but she's not so willing to leave, as someone's paying her a lot to solve the same case Sam and Dean are investigating.
Izzie and George's new-founded relationship results in them having bad sex. Callie's Chief Resident position is taken away from her, and Bailey is the humble replacement. Meredith can barely handle it with Lexie anymore.
Lana absorbs Clark's powers during a lightning storm, which she uses to break into Lex's safe and steal some incriminating evidence. After being turned away by Grant at the Daily Planet, who won't accept her stolen evidence, Lana goes after Lex herself. Clark tries to rescue Lex, but must first battle the super-powered Lana.
During a visit to New Athos, Teyla and Dr. Keller find themselves on the run from a primitive tribe of warriors.
In the sun-scorched Sahara Desert, Grylls uses survival tactics of the indigenous people, including eating a scorpion and a sandfish. He also explains how to escape from quicksand.
The Warden ask Earl to make a skit called 'scared straight' that will stop kids from committing crimes and stay out of jail. Meanwhile, Randy uses his authority to make Earl's life difficult in prison.
A police officer comes out of retirement to help out with things in Bokuto Station. Apparently the officer knows Aoi from some previous officer work, and since Aoi is still cross-dressing as a woman, the officer tries to turn Aoi into a man by giving him and the entire department some special training. Aoi doesn’t want to change his ways, but he and Natsumi stick with the training.
J.D's brother Dan returns and delivers a few home truths to his little brother. In the meantime, Elliot and Dr. Cox debate over the morals of their practice and the staff of Sacred Heart find the Janitor's behavior rather odd after he watches "An Inconvenient Truth".
Belle has a couple as clients who want a foursome, so Belle has to find a man to help out. Belle's problem: she doesn't have that many friends she could ask for such a favor.
As Wilhelmina prepares for her flamboyant wedding, she quickly realizes that her maid of honor, Victoria Beckham, is stealing all her thunder. Meanwhile, Betty is filled with guilt about her pact with Wilhelmina to keep the latter's affair a secret and Ignacio prepares for his big day as he is about to become an official U.S. citizen. However, when Betty moves in with Henry the father/daughter relationship is strained.
For their third and final Euro-mission, Sam, Clover and Alex are sent to check out the mysterious disappearances of various European fashion critics (including Beatrice Bash, editor of Fashion Slam! magazine). In a b-story, the girls are reacquainted with Guillaume, their former pool French boy… and this time they
Paranormal investigators investigate places that are reported to be haunted. Engaging forensic experts, historical records and the most innovative technology available, the squad helps everyday people who are struggling with unexplained supernatural phenomena.
When a man plans to sell a list with names from both the Berkut Group and the CIA, the companies team up to catch him. Jaime and Tom are partnered for the mission in Paris, where they find themselves struggling to balance their flirting with the task at hand. Finally, Becca tries to impress a boy and gets arrested, prompting Jonas to bail her out.
The team has two cases tonight and two great tourist locations: Madison Square Park where a man is stabbed to death, and the Metropolitan Museum of Art, where a woman is shot dead on the steps. What is even more perplexing about these cases is that the team soon realizes that these two victims hold something criminal in common.